Effective syntheses of cyclic peptides using a mixture of alkaline metals as an adjunctive cyclization reagent.

1 January 1989

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 37 (11) , 3166-3167
https://doi.org/10.1248/cpb.37.3166

Abstract

Cyclic octapeptides (1)-(3) were synthesized from the corresponding linear peptides in satisfactory yields using an equimolar mixture of the alkaline metals LiCl, NaCl, KCl, and CsCl.

Keywords

CYCLIZATION
LICL
CYCLIC
REAGENT
SYNTHESES
CORRESPONDING
SATISFACTORY
KCL
EQUIMOLAR
ADJUNCTIVE

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