Adverse Interaction Between Beta-adrenergic Blocking Drugs and Verapamil-Report of Three Cases

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Abstract
Patients [3] with ischemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and .beta.-adrenergic blocking drugs. This clinical picture resolved completely with cessation of the combined therapy. Baseline left ventricular function, assessed by cardiac catherization or nuclear angiography, was normal in 2 patients and only mildly reduced in the other. Simultaneous administration of .beta.-adrenergic blocking drugs and verapamil may result in profound adverse interactions and should only be administered with great caution.