Cloning and characterization of the entire cDNA encoded by ATP1AL1 — a member of the human Na,K/H,K‐ATPase gene family
- 25 July 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 349 (1) , 144-150
- https://doi.org/10.1016/0014-5793(94)00655-5
Abstract
The cDNA for ATP1AL1 — the fifth member of the human Na,K‐/H,K‐ATPase gene family — was cloned and sequenced. The deduced primary ATP1AL1 translation product is 1,039 amino acids in length and has M r of 114,543. The encoded protein has all of the structural features common to known catalytic subunits of P‐type membrane ion‐transporting ATPases and is equally distant (63–64% of identity from the Na,K‐ATPase isoforms and the gastric H,K‐ATPase. The ATP1ALI encoded protein was proposed to represent a new separate group within the family of human potassium‐dependent ion pumps.Keywords
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