The protection of terminal ethynyl groups in Grignard syntheses
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 1364-1366
- https://doi.org/10.1039/j39670001364
Abstract
The trimethylsilyl group can be used to protect a terminal ethynyl group in Grignard syntheses. For example, a Grignard reagent can be made in tetrahydrofuran from the easily prepared compound (p-bromophenylethynyl)-trimethylsilane, and carbonation gives the acid (p-carboxyphenylethynyl)trimethylsilane, which on treatment with dilute alkali gives p-ethynylbenzoic acid in 55% overall yield. The corresponding meta-acid can be made analogously. This method of protection has been used in the preparation of the compounds m- and p-HCC·C6H4·MR3, where MR3= SiMe3, SiEt3, or SnMe3.Keywords
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