The impact of polystyrene resins in solid-phase organic synthesis
- 1 May 1996
- journal article
- Published by Springer Nature in Molecular Diversity
- Vol. 1 (3) , 183-186
- https://doi.org/10.1007/bf01544956
Abstract
A major objective of the DIVERSOMER® technology is to provide pure and characterized compounds for biological testing in order to prevent ‘false negatives’ in our libraries. On several occasions, analysis of the final products by1H-NMR and MS, has revealed by-products from the polystyrene solid support. Subsequently, three alternative methods were studied to remove polystyrene by-products; (i) prewashing of the resin prior to execution of the synthesis; (ii) pretreatment of the resin with the cleavage conditions consistent with the solid-phase synthesis reaction scheme; and (iii) parallel purification.Keywords
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