Heterocyclic studies. Part XXXIX. Ring cleavage of some pyrimidine derivatives in alkali
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1004-1007
- https://doi.org/10.1039/p19760001004
Abstract
4-(Substituted amino)-6-chloropyrimidines bearing a mesomeric electron-withdrawing substituent such as NO2, CN, CHO, or Ac at position 5 are cleaved by dilute sodium hydroxide, often at room temperature, to yield tetrasubstituted olefins. Unlike acid-catalysed attacks on similar pyrimidines, the course of these basic reactions was not strongly influenced by steric interference between the 4(6)- and 5-substituents.Keywords
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