The pharmacokinetics and tissue penetration of FCE 22101 following intravenous and oral administration
- 1 April 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 21 (4) , 445-450
- https://doi.org/10.1093/jac/21.4.445
Abstract
One gram each of FCE 22101 and its acetoxymethyl ester (FCE 22891) were administered sequentially to six healthy volunteers. After intravenous administration Cmax was 167 mg/l, and the elimination half-life 0·8 h. Following oral administration Cmax was 6·9 mg/l and the elimination half-life 0·6 h. Penetration into inflammatory fluid was rapid, and the percentage penetration 86·1 and 60·9% following oral and intravenous dosing respectively. Urine recovery was greater after intravenous administration (31%) than after oral (11%).Keywords
This publication has 2 references indexed in Scilit:
- Comparison of in vitro activity of FCE 22101, a new penem, with those of other beta-lactam antibioticsAntimicrobial Agents and Chemotherapy, 1983
- The Influence of Protein Binding upon Tissue Fluid Levels of Six -Lactam AntibioticsThe Journal of Infectious Diseases, 1980