Hypogonadotropic hypogonadism and peripheral neuropathy inEbf2-null mice
- 15 January 2003
- journal article
- Published by The Company of Biologists in Development
- Vol. 130 (2) , 401-410
- https://doi.org/10.1242/dev.00215
Abstract
Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the Ebf2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2-/- peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development.Keywords
This publication has 34 references indexed in Scilit:
- Development of Luteinizing Hormone Releasing Hormone NeuronesJournal of Neuroendocrinology, 2001
- Development of Luteinizing Hormone Releasing Hormone NeuronesJournal of Neuroendocrinology, 2001
- Expression of gamma-aminobutyric acid and gonadotropin-releasing hormone during neuronal migration through the olfactory systemEndocrinology, 1996
- Failure of B-cell differentiation in mice lacking the transcription factor EBFNature, 1995
- Distribution of TAG‐1/Axonin‐1 in fibre tracts and migratory streams of the developing mouse nervous systemJournal of Comparative Neurology, 1994
- Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeastNature, 1993
- Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.Genes & Development, 1993
- Origin of luteinizing hormone-releasing hormone neuronsNature, 1989
- A Deletion Truncating the Gonadotropin-Releasing Hormone Gene Is Responsible for Hypogonadism in the hpg MouseScience, 1986
- Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadismNature, 1977