QUINIDINE SYNCOPE - REPORT OF SUCCESSFUL TREATMENT WITH BRETYLIUM TOSYLATE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 72  (3) , 464-467
Abstract
Quinidine syncope is an unpredictable side effect of quinidine administration which has a mortality rate of 11.5% when managed with conventional drugs and direct-current countershock. In 2 patients with quinidine syncope, the arrhythmias were effectively controlled within 30 min following the slow infusion of 150 mg of bretylium tosylate. This control is contrasted with 2 cases managed in the conventional manner. Bretylium tosylate is a quarternary amine with unique antifibrillatory properties and appears to have a significant role in the management of these arrhythmias.

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