Synthesis of β-Lactams via Intramolecular Alkylation
- 1 January 1971
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 1 (1) , 51-73
- https://doi.org/10.1080/00397917108081617
Abstract
S-Lactams are four-manbored cyclic amides (2-atatidinone) of the general structure (1) which were first synthesized by Staudingerl in 1907. Since then. numerous manbors of this fraily hrv. been preoared by a wide variety of methods. flu of the current Interest in this field is duo to the caamarcirl success of the 3-Iactam antibiotics - penicillins and crphrlolporins. In this review we have discussed from the preprrativo point of view those synthetic methods uhich involvo as the final stap the cycllation to a a-lactn through the formation of the C3 – C4 bond.Keywords
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