Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass
- 1 February 1997
- journal article
- research article
- Published by SAGE Publications in Cardiovascular Surgery
- Vol. 5 (1) , 92-98
- https://doi.org/10.1016/s0967-2109(96)00079-8
Abstract
Domestic swine (n=12 in each group) were randomized to daily treatment with the thromboxane A2 (TXA2) receptor antagonist BMS-180291 (group I), aspirin (group II), or no drug (group III) prior to prosthetic carotid graft implantation. Platelet and arterial wall receptor density were measured by equilibrium binding using 125I-BOP. At 6 weeks, means (s.e.m.) platelet receptor density (pmol/mg) had increased in groups I (3.3(0.6) versus 1.8(0.3); Plt0.05) and II (2.6(0.6) versus 1.7(0.2); Pversus 1.2(0.2)). Aortic membrane TXA2 receptor density (fmol/mg) was significantly greater (P2 receptor antagonist or aspirin is associated with increased platelet and aortic receptor density in pigs. Published by Elsevier Science Ltd.Keywords
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