Growth inhibitory activity of atrial natriuretic factor in rat glomerular mesangial cells
- 26 September 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 238 (1) , 135-138
- https://doi.org/10.1016/0014-5793(88)80242-4
Abstract
Atrial natriuretic factor (ANF) binding sites, or ANF‐induced cGMP accumulation, have been shown in numerous tissues that may not be intimately involved in volume homeostasis. In a series of experiments, we found that quiescent rat glomerular mesangial cells in culture could be reactivated to enter the cell cycle, and that ANF had potent inhibitory effects on proliferation of these cells. [3H]Thymidine incorporation increased by fivefold in reactivated compared to quiescent cells, and ANF in physiologic concentrations inhibited this incorporation by 48%. Thus, ANF appears to be a multifunctional peptide, consistent with a number of peptide growth factors.Keywords
This publication has 15 references indexed in Scilit:
- Peptide growth factors are multifunctionalNature, 1988
- Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cellsAmerican Journal of Physiology-Cell Physiology, 1988
- Atrial natriuretic factor (ANF) inhibits the growth and the secretory activity of rat adrenal zona glomerulosa in vivoThe Journal of Steroid Biochemistry and Molecular Biology, 1987
- Effect of atrial natriuretic factor on cytosolic free calcium in rat glomerular mesangial cellsFEBS Letters, 1987
- Atrial natriuretic factor and sodium nitroprusside increase cyclic GMP in cultured rat lung fibroblasts by activating different forms of guanylate cyclaseBiochemical Journal, 1987
- Rat atrial natriuretic factor suppresses proopiomelanocortinderived peptides secretion from both anterior and intermediate lobe cells and growth hormone release from anterior lobe cells of rat pituitary in vitroBiochemical and Biophysical Research Communications, 1986
- Rat atrial natriuretic polypeptide stimulation of adrenal zona glomerulosa cell growthBiochemical and Biophysical Research Communications, 1985
- The effects of cyclic nucleotides on the proliferation of cultured human T-lymphocytesImmunopharmacology, 1984
- Neutral proteinase activity produced in vitro by cells of the glomerular mesangiumKidney International, 1983
- Selective inhibition of thymidine transport at low doses of the alkylating agents triethyleneiminobenzoquinone (Trenimon)Experimental Cell Research, 1975