Intravenous 133Xe clearance in preterm neonates with respiratory distress. Internal validation of CBF∞ as a measure of global cerebral blood flow
- 1 November 1988
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 48 (7) , 673-678
- https://doi.org/10.3109/00365518809085789
Abstract
An intravenous 133Xe clearance technique is described, giving very low values of global cerebral blood flow (CBF∞) in mechanically ventilated, preterm infants. External monitoring of the chest is used to estimate the arterial input function to the brain, with a modified correction to allow for increased recirculation due to right-to-left shunting. The results compared well in 10 studies in seven infants, where CBF∞ could also be calculated from direct simultaneous blood sampling from the right radial artery (7.9 ml/100 g/min±2.5 SD vs. 8.4±3.6, p>0.05). In 25 studies in 12 infants the results compared well with those calculated from simultaneous 133Xe concentrations in expired air. Fifteen-minute clearance data gave better precision than 8-min data. The modified chest curve correction was partly effective in a case of extreme right-to-left shunting.Keywords
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