USE OF THE LOGISTIC FUNCTION FOR THE CALCULATION OF DOSE‐RATIOS AND POTENCY RATIOS

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Abstract
1 Dose-ratios and potency ratios, obtained with the guinea-pig isolated ileum by calculating matching concentrations from a least-squares fit using a logistic relationship between response and dose, differ from those obtained with the more usual assumption that response is a linear function of log dose over a limited range. 2 The differences are not due to the mathematical treatment of the results but arise from changes in sensitivity associated with the production of very high or very low responses. 3 With this preparation there is no advantage in avoiding the linear transformation and fitting the results to the complete dose-response curve though this might not apply to results obtained from other tissues with less variable sensitivity.