Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells
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Open Access
- 1 August 2001
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 167 (3) , 1137-1140
- https://doi.org/10.4049/jimmunol.167.3.1137
Abstract
CD4+CD25+ regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4+CD25− T cells and are potent suppressors of CD4+CD25− T cell activation in vitro. We demonstrate that CD4+CD25+ T cells also suppress both proliferation and IFN-γ production by CD8+ T cells induced either by polyclonal or Ag-specific stimuli. CD4+CD25+ T cells inhibit the activation of CD8+ responders by inhibiting both IL-2 production and up-regulation of IL-2Rα-chain (CD25) expression. Suppression is mediated via a T-T interaction as activated CD4+CD25+ T cells suppress the responses of TCR-transgenic CD8+ T cells stimulated with soluble peptide-MHC class I tetramers in the complete absence of APC. These results broaden the immunoregulatory role played by CD4+CD25+ T cells in the prevention of autoimmune diseases, but also raise the possibility that they may hinder the induction of effector CD8+ T cells to tumor or foreign Ags.Keywords
This publication has 23 references indexed in Scilit:
- Differentiation of Subsets of CD4 + and CD8 + T CellsPublished by Wiley ,2007
- Regulatory T CellsCell, 2000
- Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse modelsImmunological Reviews, 1999
- Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.International Immunology, 1998
- Regulation of self-tolerance by CD80/CD86 interactionsCurrent Opinion in Immunology, 1997
- The role of CD4 and CD8 T cells in type I diabetes in the NOD mouseResearch in Immunology, 1997
- T Cell-Mediated Maintenance of Natural Self-Tolerance: its Breakdown as a Possible Cause of Various Autoimmune DiseasesJournal of Autoimmunity, 1996
- CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.The Journal of Experimental Medicine, 1996
- Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid miceInternational Immunology, 1993
- Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.The Journal of Experimental Medicine, 1993