ADAPTATION IN HUMAN-SUBJECTS TO THE EFFECTS OF INHALED OZONE AFTER REPEATED EXPOSURE

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Abstract
Single exposures to low concentrations of air pollutant O3 (0.4-0.5 ppm) resulted in decrements in forced vital capacity [FVC] and specific airway conductance [SAC]. To establish whether adaptation might occur with repeated exposure, 14 normal human subjects were exposed on 5 consecutive days to 0.4 ppm of O3 for 3 h/day in an environmental chamber. Measurements of FVC and SAC obtained after exposure to O3 were compared to corresponding control values obtained during the previous week, when the same subjects breathed filtered air in the environmental chamber for 3 h/day on 5 consecutive days at the same time of day. The FVC was significantly lower than the control value on the 1st 3 days of exposure to O3 but there was no significant difference on the 4th and 5th days. Specific airway conductance was significantly lower than the control value on the 1st and 2nd days of exposure to O3; no significant differnce was noted on the 3rd, 4th or final day. All subjects were symptomatic on the 1st and 2nd days of exposure to O3. Symptoms resolved with only 1 subject remaining symptomatic on the final day of exposure to O3.

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