Studies on Carrier Substances of DNCB Contact Allergy

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Abstract
To elucidate the sensitization mechanism of allergic contact dermatitis isolation of carrier substances from DNCB-treated epidermis was attempted. The homogenate of the epidermis was found to contain immunogenic substances. One of its subcellular fractions could elicit intense contact hypersensitivity although it contained less amounts of haptenic groups than other fractions. Electron microscopy revealed it to be the microsomal fraction of epidermal cells. Treatment of the fraction with deoxycholic acid caused slight reduction of its immunizing ability.

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