Studies of random Black and White populations in North Carolina

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Abstract
As HLA testing is becoming a major vehicle for parentage determination with non-excluded, alleged fathers being compared to their racial peers, it is important to ensure that the population data used accurately reflect the genetic profile of the region from which the alleged fathers are drawn. Data on the HLA profile of Black and White residents of North Carolina are presented. Significant differences were observed for certain antigens when the North Carolina data were compared to nationally derived population tables. Differences were observed for B7 (increase) and Bw16 (decrease) in Whites and A10 (decrease), B7 (increase) and Bw42 (decrease) in Blacks. Internal controls comparing the testing from the 2 participating centers showed complete agreement for White persons, but a significant difference for B5 between the 2 Black populations.

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