Supplementary Feeding during the Preweaning Period

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Abstract
The present study was undertaken to determine if a model system could be established in the rat to produce hypercellularity of adipose tissue by overfeeding the preweaning period comparable to the eating pattern which has been suggested as contributing to one form of human obesity. To produce the hypercellularity, rat pups were given 4 supplementary feedings daily during the preweaning period. Supplementation resulted in significant differences in carcass composition, early in percent of fat (14 and 20 days) and later, in percent of protein (40 and 105 days of age). Although there was no significant difference in cell number between the supplemented and control rats, there were significant differences in cell size, the supplemented animals having larger cells at 40 and 105 days of age. The pattern of cellularity produced by supplementation was, therefore, different than that produced by other techniques of early overnutrition.

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