CEREBROSPINAL-FLUID HOMOVANILLIC-ACID IN MALE ALCOHOLICS - EFFECTS OF DISULFIRAM

  • 1 January 1977
    • journal article
    • research article
    • Vol. 12  (5) , 635-642
Abstract
The possibility that some of disulfiram''s effects are related to alterations in biogenic amine metabolism led to the study of CSF amine metabolites in a group of human alcoholics. Disulfiram treatment was associated with significant reduction in homovanillic acid, the major metabolite of dopamine, while no change was noted in 5-hydroxyindoleacetic acid, the major metabolite of serotonin. Prior to disulfiram, patients with withdrawal symptoms had significantly lower homovanillic acid than those without such symptoms.

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