HOMOLOGOUS SERUM JAUNDICE ASSOCIATED WITH USE OF IRRADIATED PLASMA
- 16 September 1950
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 144 (3) , 228-229
- https://doi.org/10.1001/jama.1950.02920030016006
Abstract
The problem of homologous serum jaundice, which first became evident during World War II, has been studied extensively. A number of studies1have variously estimated the attack rate from this disease in recipients of unirradiated pooled human plasma during the six month period after transfusion to be from 4.5 per cent to 11.9 per cent. On the other hand, Oliphant and co-worker2and Blanchard and associates3have reported favorably on the value of ultraviolet irradiation as a method of sterilizing human plasma and thereby preventing the transmission of homologous serum jaundice. In contrast, MacCallum,4in two experiments employing a less refined irradiation technic, failed to inactivate this virus in human serum. Since April 1949, the National Institutes of Health have required the irradiation of human plasma as a prerequisite to licensing manufacturers.5Neefe,6in critically evaluating the evidence available for the effectiveness of thisKeywords
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