THE EARLY REDUCTION IN UTERINE RESPONSE TO ALPHA-ESTRADIOL IN THE PARTIALLY HEPATECTOMIZED RAT, AND THE SUBSEQUENT ENHANCEMENT DURING ACTIVE LIVER REGENERATION12

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Abstract
CONSIDERABLE evidence has been marshalled in support of the hypothesis that the liver plays an important role in the inactivation of the estrogens and other steroid hormones (cf., Zondek, 1941; Burrows, 1945). Especially pertinent to the present study are the observations of a number of investigators that the response of the rat to estrogen is potentiated by toxic damage to the liver and by partial hepatectomy (e.g., Talbot, 1939; Pincus and Martin, 1940; Segaloff, 1946). On the other hand, Szego and Roberts (1945), employing the eviscerate preparation, have demonstrated that the viscera are essential for the uterine water response to estrogen in the ovariectomized rat. This work has now been extended to the partially hepatectomized animal.