31P-NMR investigation of solid tumours in the living rat
- 1 April 1981
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 1 (4) , 319-325
- https://doi.org/10.1007/bf01114871
Abstract
The 31P-NMR spectra of living tumors (Walker 256 carcinosarcomas) were obtained using surface coils and were unlike those of normal tissues. Contrary to expectations, their intracellular pH (measured from the chemical shift of the pi peak) was only slightly more acid than that of normal rat muscle, and glucose infusion did not depress it. When deoxyglucose was infused, the tumor intracellular pH measured from the chemical shift of the deoxyglucose-6-phosphate peak was much lower (6.44 .+-. 0.02) than that measured from the phosphate peak (7.14 .+-. 0.01).This publication has 17 references indexed in Scilit:
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