Defects of Tooth Structure in Congenital Cytomegalovirus Infection

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Abstract
In most populations congenital cytomegalovirus (CMV) infections occur with a frequency of 0.5% to 2% of live births. In the newborn period this infection is largely clinically inapparent; only 5% to 10% of infected infants manifest illness.1 In this small group of symptomatic babies, both the type and severity of abnormalities have a wide spectrum.2 The most frequent manifestations are microcephaly, hepatosplenomegaly, petechia, jaundice, and growth retardation. Although signs of central nervous system involvement are not usually evident at birth, they become apparent within the first few years of life in nearly 90% of children with symptoms at birth. The most common manifestations are microcephaly (70%), intellectual impairment (60%), neuromuscular disorder (35%), hearing loss (30%), and chorioretinitis or optic atrophy (22%).

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