Catabolism of Cholesterol by Bovine Adrenal-Cortex Enzymes: in vitro Formation of Oxygenated Sterols and Side-Chain Cleavage Products

Publisher Website
Google Scholar
Abstract
The identification of sterols and steroids formed by incubation of [7.alpha.-3H, 26-14C]cholesterol with mitochondrial enzymes from bovine adrenal cortex is reported. Only 17% of the radioactivity associated with cholesterol metabolites was in pregnenolone, whereas 15% was reliable to oxygenated sterols and 6% to steroid compounds. The significance of the formation of these compounds is discussed particularly as regards oxygenated cholesterol derivatives.