Studies on Glycan Processing Inhibitors: Synthesis of N-Acetylhexosamine Analogs and Cyclic Carbamate Derivatives of 1-Deoxynojirimycin
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 10 (1) , 25-45
- https://doi.org/10.1080/07328309108543888
Abstract
1-Deoxynojirimycin (1,5-dideoxy-1,5-imino-D-glucitol) was converted, via epoxide intermediates, into a series of N-acetyl-hexosamine analogs, i. e., 2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol, 2-acetamido-1,2,5-trideoxy-1,5-imino-D-mannitol, 2-acetamido-1,2,5-trideoxy-1,5-imino-D-galactitol, and their isomers. The cyclic 5-N,6-O-carbamoyl derivatives of 1-deoxynojirimycin were also prepared.Keywords
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