Characterization of human interferon-gamma-producing leukocytes with monoclonal antileukocyte antibodies
- 1 March 1983
- journal article
- research article
- Published by Springer Nature in Medical Microbiology and Immunology
- Vol. 171 (4) , 215-223
- https://doi.org/10.1007/bf02123495
Abstract
Monoclonal antibodies with specificities for subsets of human leukocytes have been used for the characterization of interferon (IFN)γ-producing cells. The production of IFNγ was demonstrated to be a function of OKT3+ T lymphocytes. The capacity to secrete IFNγ was not restricted to the OKT4+ or the OKT8+ T-cell subset. BA-1+ B lymphocytes and Leu7+ natural killer cells did not contribute to the production of IFNγ. Ia+, OKM1+ monocytes served an auxiliary function in the production of IFNγ. The requirement for accessory monocytes, however, was not absolute, because monocyte-free preparations of long-term cultured IL2-dependent T lymphocytes retained the capacity to secrete IFNγ.This publication has 31 references indexed in Scilit:
- Retinoic acid suppression of human leukocyte interferon productionImmunopharmacology, 1982
- Production of immune interferon is regulated by more than one T cell subset: Lyt‐1,2,3 and Qat‐5 phenotypes of murine T lymphocytes involved in IFN‐γ production in primary and secondary mixed lymphocyte reactionEuropean Journal of Immunology, 1982
- Immune (γ) interferon produced by a human T-lymphoblast cell lineNature, 1981
- Production of immune interferon by murine T-cell clones from long-term culturesNature, 1981
- The structure of one of the eight or more distinct chromosomal genes for human interferon-αNature, 1980
- Isolation and structure of a human fibroblast interferon geneNature, 1980
- Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferonCellular Immunology, 1980
- Interferon production in the murine mixed lymphocyte culture. I. Interferon production caused by differences in the H‐2 K and H‐2 D region but not by differences in the I region or the M locusEuropean Journal of Immunology, 1979
- Fluorescence-activated cell sorting of human T and B lymphocytes: II. Identification of the cell type responsible for interferon production and cell proliferation in response to mitogensCellular Immunology, 1974
- The interaction of human macrophages and lymphocytes in the phytohemagglutinin-stimulated production of interferonJournal of Clinical Investigation, 1971