Doxorubicin−Poly(acrylic acid) Complexes: Interaction with Liposomes
- 2 July 2004
- journal article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 20 (16) , 6575-6579
- https://doi.org/10.1021/la0497144
Abstract
Complexation of antitumor drug, doxorubicin (DOX), with poly(acrylic acid) (PAA) in buffer solutions was examined. The DOX-to-PAA binding was governed by electrostatic and stacking interactions resulting in a complex of characteristic composition with a PAA/DOX = 1.6 molar ratio. Sizes of the complex particles were found to lie in 600-900-nm range. However, the particles were able to interact with small neutral egg yolk lecithin liposomes (80-100 nm in diameter), a ternary DOX/PAA/liposome complex being formed. The observations and conclusions we made may be useful for interpreting biological effects of polymer-based bioactive constructs.Keywords
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