Isolated Deficiency of Follicle-Stimulating Hormone: Further Studies

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Abstract
We record further studies over the past 2 yr on a unique female subject with isolatedfollicle-stimulating hormone (hFSH) deficiency, who developed human anti-hFSH antibodies after treatment with exogenous urinary gonadotropins. Administration of LRH resulted in a significant risein serum hLH, but hFSH levels remained undetectable. “α Subunit” (the common achain ofthe glycoprotein hormones) was detectable in basal samples obtained from our patient, and rose sharply after LRH. This is concordant with the hypothesis that the defect in our subject may be in the synthesis of the β chain of hFSH, but it does not exclude other possibilities. The concentrat on of hFSH antibodies in the patient's serum has been monitored and her response to afurther cou se of exogenous gonadotropins is recorded. The antiserum exhibits specificity for thehFSH molecu e; the a and the β chains of hFSH are virtually inert in competing with tracer 125I-hFSH for binding to the antibody. (J Clin Endocrinol Metab40:790, 1975)

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