Metabolism of Rotenone in vitro by Tissue Homogenates from Mammals and Insects
- 10 February 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 155 (3763) , 713-716
- https://doi.org/10.1126/science.155.3763.713
Abstract
Hydroxylation of rotenone in vitro in the enzyme system composed of microsomes and reduced nicotinamide-adenine dinucleotide phosphate, and in living mice and houseflies, yields products tentatively identified as rotenolone I; rotenolone II; 8′-hydroxyrotenone; 6′,7′-dihydro-6′,7′-dihydroxyrotenone; two rotenolones of each of the last-mentioned two compounds; and uncharacterized polar materials. The toxicity of certain of these rotenoids to mice is of the same order as that of rotenone.Keywords
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