Effects of Septal Lesions on Enzymes of Acetyl‐CoA Metabolism in the Cholinergic System of the Rat Hippocampus

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Abstract
Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP-citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the 2 enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl-CoA synthase and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. ATP-citrate lyase is linked to the septal-hippocampal pathway and the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.