Chlamydia trachomatisserovar E isolates from patients with different clinical manifestations have similar courses of infection in a murine model: host factors as major determinants ofC trachomatismediated pathogenesis

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Abstract
Background:Some investigators have proposed an association between certainChlamydia trachomatisserovars and the clinical course of infection in humans. A recent study of over 1100 patients with culture confirmed and serotypedC trachomatisurogenital infection detected no such association.Aims:To corroborate these results using a murine model of female genital tract infection.Methods:Various parameters of infection were assessed in mice intravaginally infected with human genital isolates ofC trachomatisserovar E from four cases with either a clear symptomatic or asymptomatic clinical course in both the patient and their partner.Results:No differences were seen among the strains in the incidence or duration of infection, polymorphonuclear granulocyte responses, or upper genital tract progression.Conclusions:An investigation to determine the correlation between the clinical manifestations of different isolates ofC trachomatisserovar E in humans and certain parameters of microbial pathogenesis in a mouse model failed to reveal an association between the measured parameters and the tendency of serovar E to produce symptomatic versus asymptomatic infections in humans. These findings suggest that differences in the clinical course of infection in humans seen with these strains may be more related to host factors than to genetic variation among strains.

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