The Plasminogen‐PIasmin Content of Umbilical Cord Blood

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Abstract
Summary: The plasminogen contents of the blood of the umbilical vessels and of the maternal peripheral vein were determined. The plasminogen content of the umbilical artery blood varied from 0.2 to 10.1 caseinolytic units per ml. of serum and that of the umbilical vein blood from 2.7 to 9.8 caseinolytic units per ml. of serum. In the maternal peripheral vein, the plasminogen content varied from 7.5 to 15.6 caseinolytic units per ml. of serum.The average fibrinogen content in the umbilical vein was 298 mg. per 100 ml. of plasma and in maternal peripheral plasma it was 487 mg. per 100 ml.In this series, where greater spontaneous activity was detected in the umbilical artery than in the umbilical vein, the plasminogen content of the umbilical artery was correspondingly lower than that of the umbilical vein. It is postulated that this is because of increased utilization of plasminogen.Since in many cases there was no difference in spontaneous ‐plasmin activity and plasminogen content in arterial and venous cord bloods, it is considered also that in the cases where there was increased plasmin activity and decreased plasminogen content a recent intervillous thrombosis had occurred.

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