Fluid-Management Strategies in Acute Lung Injury — Liberal, Conservative, or Both?

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Abstract
One of the factorial assessments carried out in the Fluids and Catheters Treatment Trial (FACTT) conducted by the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, the results of which are reported by Wiedemann et al. in this issue of the Journal, 1 was to determine whether a conservative or a liberal strategy of fluid management was more effective in patients with established acute lung injury. Although there was no difference in mortality at 60 days between the two treatment groups, patients in the group treated according to a conservative strategy of fluid management had . . .