Transplantation of Hepatocytes for Treatment of Surgically Induced Acute Hepatic Failure in the Rat

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Abstract
Efficacy of transplanted hepatocytes was evaluated in rats with a surgically induced acute hepatic failure. After 75% liver resection and portacaval shunt, the intrasplenic or i.p. injection of 20 million isolated fresh hepatocytes significantly reduced the mortality rate. The transplantation of isolated hepatocytes may prevent death in rats with acute hepatic failure, and hepatocyte transplantation may act by a mechanism of hepatic support.