Chronic Lymphadenopathy and Sjögren's Syndrome in a Homosexual Man

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Abstract
To the Editor: We have recently encountered a homosexual man with the chronic lymphadenopathy syndrome and a Sjögren's-like illness. Autoimmune phenomena have been described in homosexual men and attributed to nonspecific B-lymphocyte activation and intense antibody formation.1 , 2 We suggest that a similar immunoglobulin-mediated mechanism may be responsible for the development of the Sjögren's-like syndrome in this patient.A 58-year-old homosexual man was hospitalized with an eight-month history of extreme malaise, chronic nonproductive cough, persistent low-grade fevers, night sweats, a 20-kg weight loss, hoarseness, xerophthalmia, and xerostomia. An oral temperature of 38.3°C, dry oral mucosa without ulcerations, generalized lymphadenopathy, and scattered . . .

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