A customized and versatile high-density genotyping array for the mouse
Open Access
- 9 August 2009
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 6 (9) , 663-666
- https://doi.org/10.1038/nmeth.1359
Abstract
This array with 623,124 SNP probes and 916,269 probes to query structural variants opens the door to a detailed characterization of genetic diversity in laboratory mouse strains. This will allow genome-wide association studies in mice. We designed a high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation, and will extend the successes of human genome-wide association studies to the mouse.Keywords
This publication has 17 references indexed in Scilit:
- A Common and Unstable Copy Number Variant Is Associated with Differences in Glo1 Expression and Anxiety-Like BehaviorPLOS ONE, 2009
- Gene Expression and Isoform Variation Analysis using Affymetrix Exon ArraysBMC Genomics, 2008
- The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems geneticsMammalian Genome, 2008
- Mouse segmental duplication and copy number variationNature Genetics, 2008
- An imputed genotype resource for the laboratory mouseMammalian Genome, 2008
- Widespread Monoallelic Expression on Human AutosomesScience, 2007
- A sequence-based variation map of 8.27 million SNPs in inbred mouse strainsNature, 2007
- A High-Resolution Map of Segmental DNA Copy Number Variation in the Mouse GenomePLoS Genetics, 2007
- A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse GenomePLoS Biology, 2006
- The mosaic structure of variation in the laboratory mouse genomeNature, 2002