Characterization of the Hanganutziu-Deicher (Serum-Sickness) Antigen as Gangliosides Containing N-Glycolylneuraminic Acid

Abstract
Gangliosides that possess the same sugar sequence but differ in the type of sialic acid (N-acetyl- or N-glycolylneuraminic acid) were compared for their reactivity with Hanganutziu-Deicher (serum sickness) [human] antibodies by double-diffusion gel precipitation tests. Only N-glycolylneuraminic acid containing gangliosides formed precipitation lines with Hanganutziu-Deicher antibodies, thus suggesting that Hanganutziu-Deicher antigens are gangliosides that contain N-glycolylneuraminic acid.

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