MAMMALIAN CILIATED RESPIRATORY EPITHELIUM: Studies with Particular Reference to Effects of Menthol, Nicotine, and Smoke of Mentholated and Nonmentholated Cigarettes
- 1 November 1952
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 56 (5) , 494-503
- https://doi.org/10.1001/archotol.1952.00710020518004
Abstract
THE PRESENT study was undertaken to determine the effects of menthol, nicotine, and the smoke of mentholated and nonmentholated cigarettes on excised mammalian respiratory epithelium from humans, rabbits, and rats. Previous studies on the effects of menthol on ciliated epithelium and on the respiratory tract have given equivocal findings. Proetz1 reported that a 1% solution of menthol in liquid petrolatum had no effect on the ciliary activity of excised tissue immersed in it for 84 minutes. Similarly, Haggard and Greenberg2 could find no toxic or irritant action of menthol in concentrations contained in the smoke of mentholated cigarettes on the respiratory tract of rats. Mendenhall and Shreeve,8 however, reported that smoke solutions from cigarettes produced a depression in the ciliary rate of sections of calf's trachea and that smoke solutions from mentholated cigarettes caused a greater decrease in rate than did those from nonmentholated cigarettes. Further, FoxKeywords
This publication has 1 reference indexed in Scilit:
- THE EFFECT OF CAMPHOR, EUCALYPTOL AND MENTHOL ON THE NASAL MUCOSAJAMA Otolaryngology–Head & Neck Surgery, 1930