Computed tomography assisted volumetric analysis of primary liver tumor as a measure of response to therapy

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Abstract
SERIAL COMPUTED TOMOGRAPHY ASSISTED VOLUMETRIC ANALYSES were made in 33 patients with hepatoma. Thirteen of 27 patients with tumor volumes less than 2,290 cc had a partial response to experimental therapy. However, only three of these patients also demonstrated a significant change in liver volume. Tumor volume determinations made by the method described are an accurate (× 10%) and reproducible way to measure response to therapy. In spite of small changes in total liver volume, there may be concomitantly substantial changes in tumor volume.