TPA‐induced activation of MAP kinase
- 23 September 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 290 (1-2) , 77-82
- https://doi.org/10.1016/0014-5793(91)81230-6
Abstract
Threonine and tyrosine residue phosphorylation of a 42 kDa protein identified as mitogen-activated protein kinase (MAP kinase) was stimulated in extracts from TPA-pretreated cells. It is further shown that TPA pretreatment leads to the enhancement of an activity that will induce reactivation of dephosphorylated/inactivated MAP kinase. This TPA-induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.Keywords
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