Effects of Celecoxib and Naproxen on Renal Function in the Elderly

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Abstract
ANTI-INFLAMMATORY and analgesic medications represent the most frequently used drug therapy in the adult population, and, by virtue of an age-related increase in osteoarthritis and musculoskeletal disorders, the use of these agents is particularly extensive in the elderly.1,2 Also associated with aging is a progressive decline in renal function.3,4 Studies of healthy men and women demonstrate a decline in glomerular filtration rate (GFR) of approximately 10 mL/min per 1.73 m2 per decade beginning after 30 years of age.3,4 This decline in renal function has particular implications for the safe use of nonsteroidal anti-inflammatory drug (NSAID) therapy in the elderly, since a decrease in renal perfusion may place these individuals at increased risk of NSAID-induced, acute renal impairment.5-7 In addition to hemodynamically mediated acute renal failure, other renal syndromes and side effects associated with NSAID use have been characterized.8,9