Enhancement of immune responses and possible inhibition of suppressor cells by aclacinomycin A.

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Abstract
Antitumor antibiotics were examined to determine if they possess activity which inhibits preferentially suppressor cells in comparison with effector cells. In screening for such compounds among known antibiotics, aclacinomycin augmented antibody formation and delayed-type hypersensitivity in mice over a wide concentration range. The addition of aclacinomycin to mouse spleen cell cultures also enhanced antibody formation in vitro. The generation of suppressor cells or the suppressor activity per se in mice immunized with high doses of SRBC [sheep red blood cells] was reduced by aclacinomycin. The drug may possibly inhibit suppressor cells selectively. The administration of aclacinomycin at low doses exhibited antitumor effects on [mouse] IMC carcinoma cells; the effect was not dose-dependent.