Localization of glomerular ‘deposits’ in Henoch‐Schönlein nephritis

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Abstract
Twenty-five renal biopsies from patients with Henoch-Schoenlein nephritis were examined using light microscopy, immunofluorescence, 1 .mu.m plastic-embedded sections and EM. The 1 .mu.m plastic-embedded sections and EM showed deposits in mesangial, subendothelial and subepithelial sites. Some of the latter were very large and similar to those which were described as humps in acute proliferative glomerulonephritis. Immunofluorescence showed the mesangial deposition of Ig[immunoglobulin]G, IaA and C3 [3rd component of complement] with extension into a peripheral position in some cases. Fibrin was frequently found associated with crescents. The case for Henoch-Schoenlein disease being mediated, in part at least, by immune complex deposition is presented.