Effect of Daily Exposure to 15 r Radiation on Susceptibility of Mice to Experimental Infection.

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Abstract
CF-1 female mice were exposed to approximately 15 r a day X-radiation for 9-15 weeks and challenged at intervals by intraperitoneal inoculation with graded doses of Pseudomonas aeruginosa. Comparison of the LD50 of irradiated and control mice in each challenge showed that between the 9th and 15th weeks a slight but demonstrable increase in susceptibility to the experimental infection had occurred. The increase caused by an accumulation of 1350 r during 15 weeks exposure was, however, very much less than that which had been found to result from a single acute exposure to 300 r X-radiation. Leucocyte counts gradually declined during 15 weeks exposure to 15 r/d to 2200 (Geometric mean).

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