Genetic variation in the purine nucleoside phosphorylase activity of sheep red cells
- 24 April 2009
- journal article
- Published by Wiley in Animal Blood Groups and Biochemical Genetics
- Vol. 7 (1) , 109-117
- https://doi.org/10.1111/j.1365-2052.1976.tb01384.x
Abstract
The purine nucleoside phosphorylase (NP) activity of sheep red cells was determined by starch gel electrophoresis and by a spectrophotometric assay technique. Some sheep had high activity (NP-high type) and some had low or zero activity (NP-low type). The enzyme deficiency is apparently confined to the red cell since other tissues from NP-low type animals had activities similar to those from NP-high type individuals. Family data indicated that NP activity is controlled by a pair of autosomal allelic genes, designated NPH and NPL. Sheep heterozygous for the NP genes had lower enzymic activities than homozygous high-type individuals. The frequency of NP types in different breeds of sheep was determined. Barbary and Mouflon sheep had activities similar to NP-high type domestic sheep; goats had high enzyme activities but their NP had a slower electrophoretic mobility than that of sheep.Keywords
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