THE SPECIFIC INHIBITION OF THE ENZYMATIC AMINOACYLATION OF VALYL- AND TYROSYL-sRNA BY PERIODATE-OXIDIZED sRNA
- 1 January 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 53 (1) , 91-96
- https://doi.org/10.1073/pnas.53.1.91
Abstract
Degradation of sRNA by periodate oxidation or exonuclease digestion yielded products which competively inhibited the aminoacylation of native sRNA. The inhibition was specific for a given amino acid acceptor. Periodate oxidation of preparations enriched in tyrosyl-sRNA and poor in valyl-sRNA yielded an inhibitor effective in the tyrosine system and ineffective in the valine system. Similar specificity was observed with a periodate-treated fraction which had been enriched in valine acceptor activity.Keywords
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