Quantitative Assessment of the SR Ca 2+ Leak-Load Relationship
- 4 October 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 91 (7) , 594-600
- https://doi.org/10.1161/01.res.0000036914.12686.28
Abstract
Increased diastolic SR Ca2+ leak (Jleak) could depress contractility in heart failure, but there are conflicting reports regarding the Jleak magnitude even in normal, intact myocytes. We have devel...Keywords
This publication has 26 references indexed in Scilit:
- Phospholamban Decreases the Energetic Efficiency of the Sarcoplasmic Reticulum Ca PumpJournal of Biological Chemistry, 2001
- Large Currents Generate Cardiac Ca2+ SparksBiophysical Journal, 2001
- PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor): Defective Regulation in Failing HeartsPublished by Elsevier ,2000
- Control of Maximum Sarcoplasmic Reticulum Ca Load in Intact Ferret Ventricular MyocytesThe Journal of general physiology, 1998
- The effect of tetracaine on stimulated contractions, sarcoplasmic reticulum Ca2+ content and membrane current in isolated rat ventricular myocytesThe Journal of Physiology, 1998
- Assessment of intra-SR free [Ca] and buffering in rat heartBiophysical Journal, 1997
- The effect of tetracaine on supontaneous Ca2+ release and sarcoplasmic reticulum calcium content in rat ventricular myocytesThe Journal of Physiology, 1997
- Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytesBiophysical Journal, 1995
- Na-Ca Exchange is Required for Rest-decay but not for Rest-potential of Twitches in Rabbit and Rat Ventricular MyocytesJournal of Molecular and Cellular Cardiology, 1994
- Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart MuscleScience, 1993