ORAL TREATMENT OF GREAT ICHTHYOTIC DISORDERS BY ETHYLESTER RETINOID

  • 1 January 1978
    • journal article
    • research article
    • Vol. 105  (5) , 465-468
Abstract
Observations of 3 different great ichthyotic disorders, no longer responding to local keratolytics and to oral vitamin A were reported: a case of erythrokeratoderma variabilis, 1 of ichthyosiform erythroderma and 1 of bullous ichthyosiform hyperkeratosis. After a week of oral treatment by the ethylester retinoid (Ro 10-9359), the hyperkeratotic component of each disease already improved dramatically. A maintenance treatment was continued. With equal or superior keratolytic effects, the retinoid has lower toxicity and less important side-effects than retinoic acid itself. Ethylester retinoid is used in the oral treatment of these great hyperkeratonic disorders.