Studies on Organ Specificity

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Abstract
Summary: By means of zone electrophoresis of human thyroiditis serum, the major protein groups have been isolated. Subsequent serologic testing by agglutination of tanned and coated erythrocytes has demonstrated that human thyroid auto-antibody belongs to the γ-globulin group of serum proteins. By specific absorption of thyroiditis serum followed by electrophoretic analysis of the absorbed serum, the identification of thyroid autoantibody with γ-globulin has been confirmed. Precipitation analysis indicates that thyroiditis serum can show either of two types of behavior. One type of curve is flat and broad and does not show inhibition in antibody excess; the other is tall and sharp and shows a considerable range of antibody-excess inhibition. Examination in the ultracentrifuge reveals that the human thyroid autoantibody is primarily a member of the 7 S family of serum globulins, as observed in two sera. These sera represented both kinds of precipitation characteristics.

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